Products for Research Use Only

MMP13 (M) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18209674Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18209674Size:100 µL
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Description
Rabbit polyclonal to MMP13.Matrix metallopeptidase 13 (collagenase 3) (MMP13) is a zinc-dependent endopeptidase that belongsto the matrix metalloproteinase (MMP) family. Members of the MMP family are involved in thebreakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, migration and tissue remodeling. MMP13 has been implicated in disease progressions, including arthritis, chronic ulcers and metastasis. Most MMPs are secreted as zymogens requiringactivation by an extracellular proteinase. MMP13 cleaves type II collagen more efficiently than types Iand III. It may play a role in articular cartilage turnover and cartilage pathophysiology associated withosteoarthritis.
Product Name Alternative
Anti-MMP13 antibody, anti-CLG3 antibody, anti-MANDP1 antibody
UniProt
P45452
Reactivity
Human
Immunogen
Middle region of human MMP13
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cardiovascular Disease, Epigenetics
Dilution
ELISA:1:1000-1:10000
Purity
Affinity purification
Molecular Weight
54
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
ELISA
Host or Source
Rabbit
Preservative
0.01% NaN3

UniProtKB · P45452

Collagenase 3

MMP13_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P45452
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MMP13
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.24.-
Processing
Precursor
Secondary accessions
A8K846, B2RCZ3, Q6NWN6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-bindingZinc

Biological process

Collagen degradation

Disease

Disease variantDwarfism

PTM

Disulfide bondGlycoproteinPhosphoproteinZymogen

Cellular component

Extracellular matrixSecreted

Molecular function

HydrolaseMetalloproteaseProtease

Domain

RepeatSignal

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