CAF-382

• UNSPSC Description:

  CAF-382 (compound B1) is an analog of SNS-032 and a CDKL5 and pan-CDK inhibitor with a weak GSK3α/β affinity (>1.8 μM) and inhibitory activity. CAF-382 inhibits CDKL5 and blocks the phosphorylation of the CDKL5 E2 domain[1].

• Target Antigen:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/caf-382.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C1=CN=C(O1)CSC2=CN=C(S2)NC(C3CCNCC3)=O)C

• Molecular Weight:

  366.50

• References & Citations:

  [1]Castano A, et al. Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology. Elife. 2023 Jul 25;12:e88206.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported