UBX-382

CAT: 0804-HY-160142-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-160142-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
UBX-382 is an orally active BTK PROTAC degrader with a DC50 of 4.56 nM. UBX-382 inhibits B-cell receptor signaling by targeting BTK. UBX-382 shows superior degradation activity for wild-type and mutant BTK proteins. UBX-382 inhibits tumor growth in murine xenograft models harboring wild-type or C481S mutant BTK-expressing TMD-8 cells. UBX-382 can be used for the study of B-cell-related blood cancers[1].
CAS Number
[2884554-45-2]
UNSPSC
12352005
Target
Btk; ERK; MEK; PROTACs; Syk
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ubx-382.html
Purity
96.20
Solubility
10 mM in DMSO
Smiles
O=C1C2=CC=C(N3CCC(CC3)CN4CC5=CC(NC6=NC7=C(C(NC8=C(C)C=CC=C8C)=NN7C)C=N6)=CC=C5CC4)C=C2C(N1C9C(NC(CC9)=O)=O)=O
Molecular Formula
C42H44N10O4
Molecular Weight
752.86
References & Citations
[1]Lim YS, et al. Orally bioavailable BTK PROTAC active against wild-type and C481 mutant BTKs in human lymphoma CDX mouse models. Blood Adv. 2023;7 (1) :92-105.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

Related Products

CatalogName
HY-101207NCS-382
HY-136362-01ARRY-382
HY-W008645-01NCS-382 (sodium)
HY-W952951CRBN ligand-382
HY-R03120-01Mmu-miR-382-3p mimic
HY-R00860A-01Hsa-miR-382-3p agomir
HY-R03120A-01Mmu-miR-382-3p agomir
HY-RI00860A-01Hsa-miR-382-3p antagomir
HY-RI03120A-01Mmu-miR-382-3p antagomir
HY-RI03120-01Mmu-miR-382-3p inhibitor

Alternative Products

CatalogName
MF-0121499-01UBX-382
ABC-TC0641MCF7 382
ABC-TC481SPF-382
MBS5757533NCS-382
BUP02454-01ARRY-382
ABC-TC0360HeLa-382
MBS5821268CAF-382
8105/50CAF 382
456347-01ML 382
MBS5813223NA 382

Popular Products