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Apalcillin

CAT: 0804-HY-121195Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-121195Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Apalcillin (PC-904) in combination with Ro 48-1220, a penam sulfone β-lactamase inhibitor, demonstrated broad-spectrum activity against gram-negative aerobic and anaerobic bacteria, excluding Klebsiella oxytoca. It exhibited potent activity against β-lactamase-producing Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae, with effective MICs (11 μg/mL) . The combination also inhibited Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter species at low MICs (0.25 to 4 μg/mL) . However, its efficacy against oxacillin-resistant staphylococci and certain gram-positive organisms was limited. Apalcillin/Ro 48-1220 showed comparable efficacy to piperacillin/tazobactam against some extended-spectrum β-lactamase-producing Escherichia coli but was less effective against SHV-type β-lactamases[1].
CAS Number
63469-19-2
Product Name Alternative
PC-904
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/apalcillin.html
Smiles
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](NC(C3=C(O)C4=NC=CC=C4N=C3)=O)C5=CC=CC=C5)=O)N1C2=O)O
Molecular Formula
C25H23N5O6S
Molecular Weight
521.55
References & Citations
[1]Comparative in vitro activity of apalcillin alone and combined with Ro 48-1220, a novel penam R-lactarnase inhibitor
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T210324-01Apalcillin

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