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Apalcillin

CAT: 0931-T210324-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210324-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
63469-19-2
Target
Antibacterial
Related Pathways
Microbiology/Virology
Bioactivity
Apalcillin (PC-904) combined with Ro 48-1220 (a penicillin sulfone β-lactamase inhibitor) exhibits broad-spectrum activity against Gram-negative aerobic and anaerobic bacteria, excluding Klebsiella acid-producing strains. This combination shows strong efficacy against β-lactamase-producing Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae with an effective MIC of 11 μg/mL. Additionally, it inhibits Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter at low MICs (0.25 to 4 μg/mL) . However, it has limited efficacy against oxacillin-resistant staphylococci and some Gram-positive bacteria. Apalcillin/Ro 48-1220's effectiveness against certain extended-spectrum β-lactamase-producing Escherichia coli is comparable to piperacillin/tazobactam, though it is less effective against SHV-type β-lactamases.
Smiles
N(C([C@H](NC(=O)C1=C(O)C2=C(N=C1)C=CC=N2)C3=CC=CC=C3)=O)[C@H]4[C@@]5(N([C@@H](C(O)=O)C(C)(C)S5)C4=O)[H]
Molecular Formula
C25H23N5O6S
Molecular Weight
521.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-121195Apalcillin
HY-106705Apalcillin (sodium)

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