MG2N001

• Description :

  MG2N001 is a negative allosteric modulator (NAM) (IC50: 93 nM) of the metabotropic glutamate receptor mGluR2 and binds to mGluR2 as an antagonist (Ki: 63 nM) . mG2N001 is microparticle- and plasma-stable, and its radioisotope [11C]mG2N001 can be used in PET imaging. [11C]mG2N001 has good brain heterogeneity and brain penetration, and can selectively accumulate in mGluR2-rich regions, producing high-contrast brain images[1].

• UNSPSC :

  12352005

• Target :

  MGluR; Src

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/mg2n001.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=NC2=C(C(C3=C(F)C=C(OC)C=C3)=C1)CCC(C)(C)O2)N

• Molecular Formula :

  C18H19FN2O3

• Molecular Weight :

  330.35

• References & Citations :

  [1]Yuan G, et al. Synthesis and Characterization of 5- (2-Fluoro-4-[11C]methoxyphenyl) -2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2. J Med Chem. 2022 Feb 10;65 (3) :2593-2609.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2760515-88-4]