Eicosanoyl-5-hydroxytryptamide

• Background:

  A natural product found in coffee which synergizes with caffeine in protecting the brain in models of alpha-synucleinopathy (1). It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated alpha-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance. It prevents ABeta-induced impairments in mouse models of Alzheimer’s disease (2,3).

• Description:

  A neuroprotective natural product found in coffee

• Product Name Alternative:

  Eicosanoyl serotonin; Eicosanoyl-5-hydroxytryptamide; EHT

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Neurodegeneration | Alzheimer's Disease | Tangles & Tau | Synuclein

• Purity:

  >98% (TLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  Beige powder

• Solubility:

  May be dissolved in DMSO (30 mg/ml); or ethanol (20 mg/ml, warm)

• Molecular Formula:

  C30H50N2O2

• Molecular Weight:

  470.7

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Yan R., et al. (2018) Proc. Natl. Acad. Sci. USA . 115:E12053 2. Asam K., et al. (2017) PLoS One. 12:e0189413 3. Basurto-Islas G., et al. (2014) Neurobiol. Aging. 35:2701