5-Azacytidine

• Background:

  DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.

• Description:

  DNA hypomethylation agent

• Product Name Alternative:

  4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2 (1H) -one; Ladakamycin; U- 18496; NSC-102816; 5-AzaC

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Epigenetics and Nuclear Signaling | Cancer

• Purity:

  >98% (TLC) ; NMR (Conforms)

• Weight:

  0.05

• Format:

  White Solid

• Solubility:

  Soluble in 25 mg/ml DMSO or 12 mg/ml Water

• Molecular Formula:

  C8H12N4O5

• Molecular Weight:

  244.2

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Schneider-Stock R., et al. (2005) J Pharmacol Exp Ther. 312(2): 525-536. 2. Mikkelsen T.S., et al., (2008) Nature. 454(7200): 49-55. 3. Qian Q., et al., (2012) Stem Cells Dev. 21(1): 67-75.

• CAS Number:

  320-67-2