(S) -ACE-OH

• Description :

  (S) -ACE-OH is a molecular glue with anticancer activity. (S) -ACE-OH promotes nucleoporin degradation and disruption of nucleocytoplasmic trafficking by inducing the interaction between E3 ubiquitin ligase TRIM21 and nucleoporin NUP98[1].

• UNSPSC :

  12352005

• Target :

  Molecular Glues

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/s-ace-oh.html

• Purity :

  99.17

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C[C@@H](C1=CC2=C(SC3=C(N2CCCN(C)C)C=CC=C3)C=C1)O

• Molecular Formula :

  C19H24N2OS

• Molecular Weight :

  328.47

• References & Citations :

  [1]Lu P, et al. Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders[J]. Cell, 2024.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported