(RS)-G12Di-1

• UNSPSC Description:

  (RS)-G12Di-1 is a selective, covalent inhibitor of K-Ras-G12D[1].

• Target Antigen:

  Ras

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/rs-g12di-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C#CC1=CC=CC2=CC=CC(C3=C(C4=C(C(N5CC6CCC(N6C(C7CC(O7)=O)=O)C5)=NC(OCC89CCCN8CCC9)=N4)C=N3)F)=C12

• Molecular Weight:

  646.71

• References & Citations:

  [1]Zheng Q, et al. Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D. Nat Chem Biol. Published online March 5, 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported