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Opiorphin

CAT: 0804-HY-W345510-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W345510-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2) . Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission[1][2].
CAS Number
864084-88-8
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Neprilysin
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/opiorphin.html
Purity
98.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC[C@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)N)=O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O
Molecular Formula
C29H48N12O8
Molecular Weight
692.77
Precautions
H302, H315, H319, H335
References & Citations
[1]Wisner A, et, al. Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways. Proc Natl Acad Sci U S A. 2006 Nov 21;103 (47) :17979-84.|[2]Tian XZ, et, al. Effects and underlying mechanisms of human opiorphin on colonic motility and nociception in mice. Peptides. 2009 Jul;30 (7) :1348-54.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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