Dynorphin A (1-8)

Dynorphin A (1-8)

• CAS Number: 75790-53-3
• UNSPSC Description: Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM)[1][2].
• Target Antigen: Endogenous Metabolite; Opioid Receptor
• Type: Peptides
• Related Pathways: GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/dynorphin-a-1-8.html
• Purity: 99.88
• Solubility: 10 mM in DMSO|H2O : 100 mg/mL (ultrasonic)
• Smiles: O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N
• Molecular Weight: 981.15
• References & Citations: [1]Agbas A, Ahmed MS, Millington W, et al. Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Peptides. 1995;16(4):623-627.|[2]Ahmed MS, Zhou DH, Cavinato AG, Maulik D. Opioid binding properties of the purified kappa receptor from human placenta. Life Sci. 1989;44(13):861-871.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, stored under nitrogen, away from moisture)
• Clinical Information: No Development Reported