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Dynorphin A (1-8)

CAT: 0804-HY-P2159-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2159-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM) [1][2].
CAS Number
75790-53-3
UNSPSC
12352209
Target
Endogenous Metabolite; Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dynorphin-a-1-8.html
Purity
99.88
Solubility
10 mM in DMSO
Smiles
O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N
Molecular Formula
C46H72N14O10
Molecular Weight
981.15
References & Citations
[1]Agbas A, Ahmed MS, Millington W, et al. Dynorphin A (1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Peptides. 1995;16 (4) :623-627.|[2]Ahmed MS, Zhou DH, Cavinato AG, Maulik D. Opioid binding properties of the purified kappa receptor from human placenta. Life Sci. 1989;44 (13) :861-871.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, stored under nitrogen, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; κ Opioid Receptor/KOR

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