GLIS2 rabbit pAb

CAT: 0855-ES16175-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES16175-01Size:50 µL

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Background

This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 2010]

Description

This gene is a member of the GLI-similar Zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys. [provided by RefSeq, Jan 2010],

UniProt

Q9BZE0

Swiss Prot

Q9BZE0

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from human GLIS2 AA range: 442-492

Target

GLIS2

Clonality

Polyclonal

Source

Rabbit

Applications

Concentration

1 mg/ml

Dilution

WB 1:500-2000

Buffer

-20°C/1 year

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Nucleus speckle . Cytoplasm .

Gene ID (Human)

84662

UniProtKB · Q9BZE0

Zinc finger protein GLIS2

GLIS2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9BZE0
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: GLIS2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B3KX84

Protein keywords

Molecular function

ActivatorDevelopmental proteinDNA-bindingRepressor

Disease

CiliopathyNephronophthisis

Cellular component

CytoplasmNucleus

Biological process

DifferentiationNeurogenesisTranscriptionTranscription regulation

Ligand

Metal-bindingZinc

Technical term

Proteomics identificationReference proteome

Domain

RepeatZinc-finger

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RA32464-01	GLIS2 rabbit pAb
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