MTIC-d3

MTIC-d3

• CAS Number: 1185242-69-6
• UNSPSC Description: MTIC-d3 is deuterium labeled MTIC. MTIC is the active metabolite of Temozolomide (TMZ). MITC has lower bioavailability in the brain compared with TMZ, because the agent’s permeability through biological barriers and tumor cell membranes affects bioavailability. MITC exhibits low affinity to biological membrane[1].
• Target Antigen: Drug Metabolite; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease;Others
• Field of Research: Cancer; Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: NC(C1=C(N=CN1)/N=N/NC([2H])([2H])[2H])=O
• Molecular Weight: 171.18
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Ramalho MJ, et al. Biophysical interaction of temozolomide and its active metabolite with biomembrane models: The relevance of drug-membrane interaction for Glioblastoma Multiforme therapy. Eur J Pharm Biopharm. 2019;136:156-163.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported