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MTIC-d3

CAT: 0804-HY-119696SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119696SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MTIC-d3 is deuterium labeled MTIC. MTIC is the active metabolite of Temozolomide (TMZ) . MITC has lower bioavailability in the brain compared with TMZ, because the agent’s permeability through biological barriers and tumor cell membranes affects bioavailability. MITC exhibits low affinity to biological membrane[1].
CAS Number
1185242-69-6
UNSPSC
12352005
Target
Drug Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Solubility
10 mM in DMSO
Smiles
NC(C1=C(N=CN1)/N=N/NC([2H])([2H])[2H])=O
Molecular Formula
C5H5D3N6O
Molecular Weight
171.18
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Ramalho MJ, et al. Biophysical interaction of temozolomide and its active metabolite with biomembrane models: The relevance of drug-membrane interaction for Glioblastoma Multiforme therapy. Eur J Pharm Biopharm. 2019;136:156-163.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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