I-191

• Description :

  I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist[1].

• Product Name Alternative :

  SX 810, (Rac)-RP-55788

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Protease Activated Receptor (PAR)

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/i-191.html

• Concentration :

  10mM

• Purity :

  99.14

• Solubility :

  DMSO : 8.33 mg/mL (ultrasonic)

• Smiles :

  O=C1NCCN(C(C2=CN3N=C(C4=CC=C(F)C=C4)C=C(C(C)(C)C)C3=N2)=O)C1(C)C

• Molecular Formula :

  C23H26FN5O2

• Molecular Weight :

  423.48

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Jiang Y, et al. A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells. J Pharmacol Exp Ther. 2018 Feb;364 (2) :246-257.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PAR2

• CAS Number :

  [1690172-25-8]