I-191

• Description:

  I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist[1].

• Product Name Alternative:

  SX 810, (Rac)-RP-55788

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Protease Activated Receptor (PAR)

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/i-191.html

• Concentration:

  10mM

• Purity:

  99.14

• Solubility:

  DMSO : 8.33 mg/mL (ultrasonic)

• Smiles:

  O=C1NCCN(C(C2=CN3N=C(C4=CC=C(F)C=C4)C=C(C(C)(C)C)C3=N2)=O)C1(C)C

• Molecular Formula:

  C23H26FN5O2

• Molecular Weight:

  423.48

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Jiang Y, et al. A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells. J Pharmacol Exp Ther. 2018 Feb;364 (2) :246-257.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PAR2

• CAS Number:

  [1690172-25-8]