AMXT-1501

• Description :

  AMXT1501 is a novel inhibitor of the polyamine transport system. AMXT1501 blocks tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells[1].

• UNSPSC :

  12352211

• Target :

  Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/amxt-1501.html

• Purity :

  99.44

• Solubility :

  H2O : 100 mg/mL (ultrasonic)

• Smiles :

  CCCCCCCCCCCCCCCC(NCCCC[C@@H](N)C(NCCCNCCCCNCCCN)=O)=O

• Molecular Formula :

  C32H68N6O2

• Molecular Weight :

  568.92

• References & Citations :

  [1]Hayes CS, et al. Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment. Cancer Immunol Res. 2014 Mar;2 (3) :274-85.|[2]Candace S Hayes, et al. Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment. Cancer Immunol Res. 2014 Mar;2 (3) :274-85.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Citation 01 :

  BioRxiv. 2024 Nov 17:2024.08.24.609500.|bioRxiv. 2025 January 26.|Cell Death Differ. 2024 Jul;31 (7) :910-923.|Immunity. 2025 Aug 12;58 (8) :2019-2034.e11.|Emerg Microbes Infect. 2024 Dec;13 (1) :2321981.|Immunity. 2025 Aug 12;58 (8) :2019-2034.e11.|Nat Commun. 2024 Mar 19;15 (1) :2461.|Neuro Oncol. 2025 May 27:noaf128.|Research Square Preprint. 2024 Mar 19.|The University of Texas at San Antonio. 2025.

• CAS Number :

  [441022-64-6]