Beta 2 microglobulin Recombinant Protein

• Background:

  Β2 microglobulin is also known as Beta-2-microglobulin (B2M), is a component of MHC class I molecules which belongs to the beta-2-microglobulin family. B2M is present on all nucleated cells (excludes red blood cells) . B2M associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa. An additional function of B2M is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in decreased iron uptake from food and iron release from recycled red blood cells respectively. Loss of this function causes iron excess and hemochromatosis. Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) .

• NCBI Gene ID:

  712428

• Swiss Prot:

  Q6V7J5

• Accession Number:

  Q6V7J5

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Apoptosis, Cancer, Homeostasis, Immunology, Signal Transduction

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  12.5 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Beta-2-microglobulin

• NCBI Organism:

  Macaca mulatta

• Background Reference 01:

  Güssow D., et al., 1987, J. Immunol. 139 (9) : 3132–8.

• Background Reference 02:

  Gorevic P.D., et al., 1986, Proc. Natl. Acad. Sci. U.S.A. 83:7908-7912.

• Background Reference 03:

  Argiles A., et al., 1992, Nephrol. Dial. Transplant. 7:1106-1110.

• Background Reference 04:

  Momoi T., et al., 1995, Clin. Chim. Acta 236:135-144.

• Other Product Names:

  B2M

• Tested Applications:

  WB

• Species:

  Cynomolgus monkey

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3