Vitronectin / VTN Recombinant Protein

• Background:

  Vitronectin is also known as S-protein, VN, VTN, V75. Vitronectin, a multifunctional glycoprotein, is involved in coagulation, inhibition of the formation of the membrane attack complex (MAC), cell adhesion and migration, wound healing, and tissue remodeling. The primary cellular source of vitronectin is hepatocytes. Blocking of Hic (a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

• NCBI Gene ID:

  7448

• Swiss Prot:

  P04004

• Accession Number:

  NP_000629.3

• Tag:

  Tag Free

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  20 mM Tris-HCl, Arginine, pH8.0

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  43.2 kDa

• Applications Notes:

  This protein carries no "tag". The protein has a calculated MW of 43.2 kDa. The protein migrates as 48-50 kDa under reducing (R) condition (SDS-PAGE) .

• NCBI Official Name:

  Vitronectin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kohler S, et al. 2015 Thromb Haemost. 113:125-42. (2) Salazar-Peláez LM, et al. 2015. PLoS One. 10 (3) :e0119717. (3) Paulsson M, et al. 2015. J Cyst Fibros. 14 (5) :600-7.

• Other Product Names:

  VTN, V75, VN, Vitronectin, S-protein, Serum-spreading factor

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3