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Vitronectin / VTN Recombinant Protein

CAT: 0223-11-248Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-11-248Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Vitronectin is also known as S-protein, VN, VTN, V75. Vitronectin, a multifunctional glycoprotein, is involved in coagulation, inhibition of the formation of the membrane attack complex (MAC), cell adhesion and migration, wound healing, and tissue remodeling. The primary cellular source of vitronectin is hepatocytes. Blocking of Hic (a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
CAS Number
9000-83-3
NCBI Gene ID
7448
Swiss Prot
P04004
Accession Number
NP_000629.3
Tag
Tag Free
Type
Recombinant Proteins
Source
E. coli
Purity
>90% as determined by SDS-PAGE.
Buffer
20 mM Tris-HCl, Arginine, pH8.0
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
43.2 kDa
Applications Notes
This protein carries no "tag". The protein has a calculated MW of 43.2 kDa. The protein migrates as 48-50 kDa under reducing (R) condition (SDS-PAGE) .
NCBI Official Name
Vitronectin
NCBI Organism
Homo sapiens
Background Reference 01
Kohler S, et al. 2015 Thromb Haemost. 113:125-42. (2) Salazar-Peláez LM, et al. 2015. PLoS One. 10 (3) :e0119717. (3) Paulsson M, et al. 2015. J Cyst Fibros. 14 (5) :600-7.
Other Product Names
VTN, V75, VN, Vitronectin, S-protein, Serum-spreading factor
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized

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