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VCAM-1 Recombinant Protein

CAT: 0223-91-287Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-287Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
VCAM-1 is a single-pass type I membrane protein, contains 7 Ig-like C2-type domains. It is an endothelial ligand for very late antigen-4 (VLA-4) and alpha4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.
CAS Number
9000-83-3
NCBI Gene ID
7412
Swiss Prot
P19320
Accession Number
P19320
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cancer, Immunology, Neuroscience, Signal Transduction
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 2mM CaCl2, 2mM MgCl2, 5% Threhalose, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
75.26 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Vascular cell adhesion molecule 1
NCBI Organism
Homo sapiens
Other Product Names
Vascular Cell Adhesion Protein 1, V-CAM 1, VCAM-1, INCAM-100, CD106, VCAM1, L1CAM
Species
Human
Protein ID
767974353
Physical Properties
Lyophilized

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