IL-1alpha Recombinant Protein

• Background:

  The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.

• NCBI Gene ID:

  3552

• Swiss Prot:

  Q9HBE4

• Accession Number:

  NP_000566

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Cancer, Cell Cycle, Chemokines & Cytokines, Immunology, Innate Immunity, Neuroscience, Obesity, Signal Transduction

• Buffer:

  Lyophilized from a concentrated sterile solution containing 50mM Tris-HCl buffer (pH 8.0) and 100mM NaCl. Reconstituted in sterile H2O not less than 100 μ g/ml, which can then be further diluted in other aqueous solutions.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Interleukin 1 alpha

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Interleukin-1alpha, IL-1F1, IL-1A

• Species:

  Human

• Protein ID:

  27894330

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3