B7-H6 / NCR3LG1 Recombinant Protein

• Background:

  The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.

• NCBI Gene ID:

  102121659

• Accession Number:

  XP_005578557.1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  28.4 kDa

• Applications Notes:

  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.4 kDa. The protein migrates as 38-50 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  Natural killer cell cytotoxicity receptor 3 ligand 1

• NCBI Organism:

  Macaca fascicularis

• Background Reference 01:

  Wu MR, et all., 2015, Gene Ther. 22 (8) :675-84.

• Background Reference 02:

  Phillips M, et all., 2016, Biopolymers. 106 (5) :658-72.

• Background Reference 03:

  Flajnik MF, et all., 2012 Immunogenetics. 64 (8) :571-90.

• Other Product Names:

  B7-H6, NCR3LG1, B7 Homolog 6

• Tested Applications:

  ELISA, WB

• Species:

  Cynomolgus monkey

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3