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TIGIT Recombinant Protein

CAT: 0223-92-550Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-92-550Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called WUCAM, VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155 (PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112 (PVRL2) with lower affinity, but not CD113 (PVRL3) . TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.
CAS Number
9000-83-3
NCBI Gene ID
100043314
Swiss Prot
P86176
Accession Number
P86176
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Immunology
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
13.3 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
T cell immunoreceptor with Ig and ITIM domains
NCBI Organism
Mus musculus
Other Product Names
T-cell immunoreceptor with Ig and ITIM domains, TIGIT, V-set and transmembrane domain-containing protein 3, VSTM3, REF: C1127, VSIG9
Species
Mouse
Physical Properties
Lyophilized

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