Semaphorin-4A Recombinant Protein

• Background:

  Semaphorin 4A (Sema4A, previously semB) is a Class 4 transmembrane Semaphorin with activity in the immune and nervous systems. Sema4A was first described as a molecule that enhances T cell activation and interacts with TIM2 (T cell immunoglobulin and mucin domain 2) . Mice with targeted disruption of Sema4A show defects in dendritic cellmediated T cell priming and Th1 responses. Roles for Sema4A have also been identified in the brain, the endothelium and the eye. It mediates hippocampal neuron growth cone collapse in vitro through interaction of the sema domain with plexinB1. Interaction of Sema4A with endothelial cell plexinD1 causes opposition to the angiogenic, proliferative, chemotactic and integrin mediated adhesive actions of VEGF.

• NCBI Gene ID:

  20351

• Swiss Prot:

  Q58NA1

• Accession Number:

  NP_038686

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  CHO cells

• Buffer:

  Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Sema4a, Semaphorin-B, Sema B

• Species:

  Mouse

• Protein ID:

  254553352

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3