Pyruvate kinase M2 Recombinant Protein

• Background:

  Pyruvate kinase isoform M2 (PKM2) is a member of the pyruvate kinase (PK) family, a pivotal glycolytic enzyme that is consistently changed during tumorigenesis. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets. As the rate-controlling enzyme in glycolysis, PKM2, has also been found to be expressed in embryonic, proliferating, and tumor cells, and it has been considered to be crucial for the metabolism and growth of tumor cells. Recent studies have shown that PKM2 promotes cell proliferation and suppresses cell apoptosis in various tumors. In addition, it has been reported that the PKM2 knockdown affects the Akt and ERK protein kinases.

• NCBI Gene ID:

  5315

• Swiss Prot:

  P14618

• Accession Number:

  P14618

• Tag:

  N-6 His tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Cancer, Obesity, Signal Transduction, Stem Cell

• Buffer:

  Supplied as a 0.2 um filtered solution of PBS, pH7.0, 10% glycerol. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

• Shipping Conditions:

  Dry Ice

• Calculated Molecular Weight:

  60.1 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Pyruvate kinase, muscle

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Pyruvate kinase PKM, CTHBP, OIP-3, THBP1, PKM2

• Species:

  Human

• Protein ID:

  524552373

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3