SARS-CoV-2 (COVID-19) S1 Recombinant Protein

• Background:

  Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, DPP4, CEACAM etc.. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

• NCBI Gene ID:

  43740568

• Accession Number:

  QHD43416.1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Infectious Disease, COVID-19

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  76.9 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Surface glycoprotein

• NCBI Organism:

  Severe acute respiratory syndrome coronavirus 2

• Background Reference 01:

  Wan Y, et al. J Virol. 2020. pii: JVI.00127-20.

• Background Reference 02:

  Benvenuto D, et al. J Med Virol. 2020.

• Background Reference 03:

  Chang CY, et al. AMB Express. 2020. 10 (1) :20.

• Other Product Names:

  S1 protein, Spike glycoprotein Subunit1, S glycoprotein Subunit1, Spike protein S1

• Tested Applications:

  WB

• Species:

  SARS-CoV-2

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3