Peroxiredoxin-1 Recombinant Protein

• Background:

  Peroxiredoxin-1 (PRDX1) contains 1 thioredoxin domain and belongs to the AhpC/TSA family. PRDX1 constitutively expressed in most human cells and it is induced to higher levels upon serum stimulation in untransformed and transformed cells. PRDX1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and play an important role in eliminating peroxides generated during metabolism. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. It may contribute to the antiviral activity of CD8 (+) T-cells and have a proliferative effect in cancer development or progression.

• NCBI Gene ID:

  5052

• Swiss Prot:

  Q06830

• Accession Number:

  Q06830

• Tag:

  N, C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Cancer, Cell Cycle, Homeostasis, Obesity, Signal Transduction

• Buffer:

  Supplied as a 0.2 um filtered solution of PBS, 10% glycerol, 0.1mM DTT, pH 6.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

• Shipping Conditions:

  Dry Ice

• Calculated Molecular Weight:

  25.3 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Peroxiredoxin 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Peroxiredoxin-1, Natural killer cell-enhancing factor A, NKEF-A, Proliferation-associated gene protein, PAG, Thioredoxin peroxidase 2, Thioredoxin-dependent peroxide reductase 2, PAGA, PAGB, TDPX2, PRDX1

• Species:

  Human

• Protein ID:

  767920419

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3