Products for Research Use Only

SCF Recombinant Protein

CAT: 0223-91-617Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-617Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.
CAS Number
9000-83-3
NCBI Gene ID
17311
Swiss Prot
P20826
Accession Number
P20826
Tag
Tag Free
Type
Recombinant Proteins
Source
E. coli
Field of Research
Immunology, Signal Transduction
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
18.4 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Kit ligand
NCBI Organism
Mus musculus
Other Product Names
Kit ligand, Hematopoietic growth factor KL, Mast cell growth factor, MGF, Steel factor, Stem cell factor, SCF, c-kit Ligand
Species
Mouse
Physical Properties
Lyophilized