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SCF Antibody

CAT: 0223-5165-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5165-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SCF Antibody: Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
NCBI Gene ID
4254
Swiss Prot
P21583
Accession Number
P21583
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
5165
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Recombinant Protein Test (Figure 2) : Anti-SCF antibodies (5165) detected human SCF recombinant protein at different concentrations. Recombinant Protein Test (5165) Regulated expression validation (Figure 7 & 8) : SCF expression detected by anti-SCF antibodies (5165) was up-regulated by angiotensin II (Ang II) treatment and was down-regulated by two inhibitors (Figure 7) or CNP treatment (Figure 8) . Regulated expression validation (5165)
Field of Research
Stem Cell
Purification
SCF Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1202 – A431 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (71%)
Buffer
SCF Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SCF antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human SCF has 3 isoforms, including isoform 1 (273aa, 30.9kD), isoform 2 (245aa, 27.9kD) and isoform 3 (238aa, 26.7kD) . Mouse SCF has 2 isoforms, including isoform 1 (273aa, 30.6kD) and isoform 2 (245aa, 27.6kD) . Rat SCF also has 2 isoforms, including isoform 1 (273aa, 30.7kD) and isoform 2 (245aa, 27.7kD) . 5165 can detect human and possibly detect mouse and rat.
Symbol
KITLG
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
KIT ligand
NCBI Organism
Homo sapiens
Background Reference 01
Reber et al. Euro. J. Pharmacology 2006; 533:327-40.
Background Reference 02
Jensen et al. Inflamm. Allergy Drug Targets 2007; 6:57-62.
Background Reference 03
Lukacs et al. J. Immunol. 1996; 156:3945-51.
Citation 01
26773730
Citation 02
23352981
Other Product Names
SCF Antibody: SF, MGF, SCF, FPH2, KL-1, Kitl, SHEP7, Kit ligand, Mast cell growth factor
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
134289
Physical Properties
Liquid

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