Products for Research Use Only

IL-16 Recombinant Protein

CAT: 0223-92-508Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-92-508Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Mouse interleukin-16 (IL-16) is a single chain non-glycosylated polypeptide. IL-16 is widely expressed in human tissues including spleen, thymus, lymph nodes, peripheral leukocytes, bone marrow and cerebellum. IL-16 plays an important role instimulating a migratory response in CD4+ lymphocytes, monocytes, and eosinophils, inducing T-lymphocyte expression of interleukin 2 receptor.It was originally identified as a CD8+ T cell-derived chemoattractant for CD4+ cells. In addition to its chemotactic properties, IL-16 has also been shown to suppress HIV-1 replication in vitro and appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. It may act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
CAS Number
9000-83-3
NCBI Gene ID
16170
Swiss Prot
O54824
Accession Number
O54824
Tag
N-6 His tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Chemokines & Cytokines
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM Tris,150mM NaCl, pH 8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
14.5 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Interleukin 16
NCBI Organism
Mus musculus
Other Product Names
Pro-interleukin-16, Interleukin-16, Lymphocyte chemoattractant factor, LCF, REF: C1011
Species
Mouse
Protein ID
119632232
Physical Properties
Lyophilized