Recombinant Human Interleukin-16/IL-16 Protein

Recombinant Human Interleukin-16/IL-16 Protein

• Background: Interleukin-16 (IL-16) is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity.
• Abbreviation: Interleukin-16;IL-16
• Synonyms: IL-16, IL16, Interleukin-16, LCF, Lymphocyte Chemoattractant Factor, Pro-Interleukin-16
• CAS Number: 9000-83-3
• UniProt: Q14005
• Accession Number: AAC12732.1
• Host: E. coli
• Origin Species: Human
• Tag: None
• Sequence: Met 1-Ser130
• Field of Research: Immunology
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 16-20 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.