NMNAT3 highly active Recombinant Protein

• Background:

  Mitochondrial NMNAT isoform. Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. Can use tiazofurin monophosphate as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i. e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity, mitochondrial NMNAT isoform can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NAADP+. Protects against axonal degeneration following injury.

• NCBI Gene ID:

  349565

• Swiss Prot:

  P33681

• Accession Number:

  Q96T66

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Obesity, Signal Transduction

• Concentration:

  1mg/ml

• Purity:

  >95% (SDS-PAGE)

• Buffer:

  In 50mM TRIS-HCl, pH 8.0, containing 300mM sodium chloride, 1mM DTT and 10% glycerol.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Nicotinamide nucleotide adenylyltransferase 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Nicotinamide Mononucleotide Adenylyltransferase 3, NMN Adenylyltransferase 3, NaMN Adenylyltransferase 3, EC 2.7.7.18, EC 2.7.7.1

• Species:

  Human

• Protein ID:

  30039706

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3