M-CSF R / CSF1R / CD115 Recombinant Protein

• Background:

  Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeIII subfamily of receptor tyrosine kinases (RTKs) . CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  55.2 kDa

• Applications Notes:

  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.2 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• Background Reference 01:

  Ridge, et al., 1990, Proceedings of the National Academy of Sciences 87 (4) : 1377–80.

• Background Reference 02:

  Mitrasinovic, O. M., 2005, Journal of Neuroscience 25 (17) : 4442–51.

• Background Reference 03:

  Tamimi, R. M., 2008, Cancer Research 68 (1) : 18–21.

• Background Reference 04:

  Pollard, J. W., 1994, Proceedings of the National Academy of Sciences 91 (20) : 9312–6.

• Other Product Names:

  CSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR

• Tested Applications:

  WB

• Species:

  Rabbit

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3