KIR2DL3 Recombinant Protein

• Background:

  Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8) . KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.

• NCBI Gene ID:

  3804

• Swiss Prot:

  P43628

• Accession Number:

  P43628

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Buffer:

  Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  25.4 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Killer Cell Immunoglobulin-Like Receptor 2DL3, CD158 Antigen-Like Family Member B2, KIR-023GB, Killer Inhibitory Receptor cl 2-3, MHC Class I NK Cell Receptor, NKAT2a, NKAT2b, Natural Killer-Associated Transcript 2, NKAT-2, p58 Natural Killer Cell Receptor Clone CL-6, p58 NK Receptor CL-6, p58.2 MHC Class-I-Specific NK Receptor, CD158b2, KIR2DL3, KIRCL23, NKAT2

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3