IL-8 non-lytic Recombinant Protein

• Background:

  Interleukin-8 (IL-8) was originally discovered as a neutrophil chemotactic and activating factor and is a member of the alpha (CXC) subfamily of chemokines (including also platelet factor 4, GRO, IP-10, etc.) . Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes and various tumor cell lines, produce IL-8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS and viruses. IL-8 has a wide range of other proinflammatory effects. It is a potent chemoattractant for neutrophils and causes degranulation of neutrophil specific granules and azurophilic granules. IL-8 induces expression of the cell adhesion molecules CD11/CD18 and enhances the adherence of neutrophils to endothelial cells and subendothelial matrix proteins. Besides neutrophils, IL-8 is also chemotactic for basophils, T cells and eosinophils. IL-8 has been reported to be a co-mitogen for keratinocytes and was also shown to be an autocrine growth factor for melanoma cells. IL-8 was also reported to be angiogenic both in vivo and in vitro.

• NCBI Gene ID:

  3576

• Swiss Prot:

  P21583

• Accession Number:

  NP_000575

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  CHO cells

• Field of Research:

  Cancer, Chemokines & Cytokines, Immunology, Signal Transduction

• Buffer:

  Lyophilized from 0.2um-filtered solution in PBS. Reconstitute in 50 μ l sterile water. Add 1X PBS to the desired protein concentration.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Chemokine (C-X-C motif) ligand 8

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Interleukin-8, CXCL8, C-X-C Motif Chemokine 8, Emoctakin, GCP-1, LAI, MDNCF, MONAP, NAP-1, NCF, TCF

• Species:

  Human

• Protein ID:

  10834978

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3