IL-23R Recombinant Protein

• Background:

  Interleukin-23 receptor (IL-23R), is a member of the type I cytokine receptor family, type 2 subfamily. It is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL-23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL-23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. IL-23R associates with IL-12RB1 to form the interleukin-23 receptor. It binds IL-23 and mediates T cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. Genetic variations in IL-23R are associated with inflammatory bowel disease type 17 (IBD17) . IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL-23R also can cause susceptibility to psoriasis type 7.

• NCBI Gene ID:

  149233

• Accession Number:

  NP_653302

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  CHO cells

• Field of Research:

  Immunology, Signal Transduction

• Buffer:

  Lyophilized from 0.2um-filtered solution in PBS. Reconstitute with 100 μ l sterile water. Add 1X PBS to the desired protein concentration.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Interleukin 23 receptor

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Interleukin-23 Receptor

• Species:

  Human

• Protein ID:

  24430212

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3