IL-23R Recombinant Protein

• Background:

  Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor beta 1 (IL12R beta 1) and IL12R beta 2, is a type I cytokine receptor for IL23. IL23R is comprised of two subunits, the IL12R beta 1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis, multiple sclerosis, Graves's ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.

• NCBI Gene ID:

  209590

• Swiss Prot:

  Q8K4B4

• Accession Number:

  Q8K4B4

• Tag:

  C-Fc tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Chemokines & Cytokines

• Buffer:

  Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  67.3 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Interleukin 23 receptor

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Interleukin-23 receptor, Il23r, IL-23 receptor, IL-23R, interleukin 23 receptor

• Species:

  Mouse

• Protein ID:

  929654682

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3