IL-18 Recombinant Protein

• Background:

  Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon- gamma (IFN- gamma) or type II interferon that plays an important role in activating the macrophages or other cells.

• NCBI Gene ID:

  3606

• Swiss Prot:

  Q14116

• Accession Number:

  Q14116

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Cancer, Chemokines & Cytokines, Immunology, Innate Immunity, Obesity, Inflammasomes

• Buffer:

  Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  23.3 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Interleukin 18

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Interleukin-18, Iboctadekin, Interferon gamma-inducing factor, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma, GIF, IL-18, IL-1g, IL1F4, MGC12320, IL-1F4

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3