Interleukin 6 Recombinant Protein (HEK293 Expressed)

• Background:

  Interleukin 6 (IL-6) is also known as HGF, BSF2, HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts, endothelial cells, et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes, atherosclerosis, depression, Alzheimer's Disease, systemic, lupus erythematosus, prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.

• NCBI Gene ID:

  3569

• Swiss Prot:

  P05231

• Accession Number:

  NP_000591

• Tag:

  Tag free

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Chemokines & Cytokines, Immunology, Neuroscience, Obesity, Signal Transduction

• Purity:

  >98% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  20.8 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Interleukin 6 (interferon, beta 2)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ferguson-Smith AC, et.al. 1988, Genomics 2 (3) : 203–8.

• Background Reference 02:

  Schwantner A, et. al. 2004, J. Biol. Chem. 279 (1) : 571–6.

• Background Reference 03:

  Schuster B, et. al. 2003, J. Biol. Chem. 278 (11) : 9528–35.

• Background Reference 04:

  Taga T, et al.1989, Cell 58 (3) : 573–81.

• Other Product Names:

  IL6, HGF, Interleukin-6, BSF2, HSF, IFNB2

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3