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IFN alpha Recombinant Protein

CAT: 0223-91-885Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-885Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interferon alpha/ beta Receptor 2 (IFN- alpha/ beta R2) is a single-pass type I membrane protein which belongs to the type II cytokine receptor family. It complexes with IFN- alpha/ beta R1 to form the signaling receptor complex for the family of alpha and beta IFN subtypes. By alternative splicing, IFN- alpha/ beta R2 can exist as a secreted soluble protein or as a type I membrane protein. IFN- alpha/ beta R2 is the principal ligand binding subunit of the receptor. Ligand binding is stabilized by the subsequent association with IFN- alpha/ beta R1, resulting in the formation of a signaling ternary receptor complex. IFNAR2 was detected in most lymphocytes, monocytes, and granulocytes, although IFNAR2 expression was higher in the monocytes and granulocytes than in the lymphocytes. Among the lymphocyte subsets, IFNAR2 showed high expression in natural killer (NK) cells and low expression in T lymphocytes. Isoform 1 and isoform 3 of IFNAR2 are directly involved in signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.
CAS Number
9000-83-3
NCBI Gene ID
3455
Swiss Prot
P48551
Accession Number
P48551
Tag
C-Fc tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cancer, Chemokines & Cytokines, Immunology, Signal Transduction
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
51.8 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Interferon alpha and beta receptor subunit 2
NCBI Organism
Homo sapiens
Other Product Names
Interferon Alpha/Beta Receptor 2, IFN-R-2, IFN-Alpha Binding Protein, IFN-Alpha/Beta Receptor 2, Interferon Alpha Binding Protein, Type I Interferon Receptor 2, IFNAR2, IFNABR, IFNARB, beta R2
Species
Human
Physical Properties
Lyophilized

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