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CD89 Recombinant Protein

CAT: 0223-91-424Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-424Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Immunoglobulin alpha Fc Receptor (IgA Fc Receptor) is a member of the immunoglobulin gene superfamily. It is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens through the charged arginin residue within its transmembrane domain. IgA Fc Receptor binds both IgA1 and IgA2 with similar affinity. The site of interaction between FCAR and IgA was identified in the first extracellular domain of FCAR and the C2/C3 junction of IgA. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. FCAR is also expressed on Kupffer cells in the liver, where it was suggested to provide a second line of defense.
CAS Number
9000-83-3
NCBI Gene ID
2204
Swiss Prot
P24071
Accession Number
P24071
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Immunology
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
24.52 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Fc fragment of IgA receptor
NCBI Organism
Homo sapiens
Other Product Names
Immunoglobulin Alpha Fc Receptor, IgA Fc Receptor, CD89, FCAR
Species
Human
Physical Properties
Lyophilized

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