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ErbB2 Recombinant Protein

CAT: 0223-91-939Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-939Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR, ERBB3 and ERBB4. HER2 associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC. And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
CAS Number
9000-83-3
NCBI Gene ID
2064
Swiss Prot
P04626
Accession Number
P04626
Tag
C-Fc tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cancer, Growth Factors, Signal Transduction, Other
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
96.5 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Erb-b2 receptor tyrosine kinase 2
NCBI Organism
Homo sapiens
Other Product Names
Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Tyrosine kinase-type cell surface receptor HER2, ERBB2, MLN19, NGL, TKR1, Her2, CD340
Species
Human
Protein ID
767957252
Physical Properties
Lyophilized

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