Ganglioside GM2 activator Recombinant Protein

• Background:

  Ganglioside GM2 activator (GM2A) is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta -hexosaminidase A (HEXB) . HEXB together with GM2A, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. GM2A accommodate several single chain phospholipids and fatty acids, is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.

• NCBI Gene ID:

  2760

• Swiss Prot:

  P17900

• Accession Number:

  P17900

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Signal Transduction, Other

• Buffer:

  Lyophilized from a 0.2 um filtered solution of 20mM TrisHCl,150mM NaCl, pH7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  18.6 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  GM2 ganglioside activator

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Ganglioside GM2 activator, Cerebroside sulfate activator protein, GM2-AP, Sphingolipid activator protein 3, SAP-3, GM2A

• Species:

  Human

• Protein ID:

  325652083

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3