ErbB2 Recombinant Protein

• Background :

  ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. Rat ERBB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays a key role in development, cell proliferation and differentiation.

• NCBI Gene ID :

  24337

• Swiss Prot :

  P06494

• Accession Number :

  P06494

• Tag :

  C-6 His tag

• Type :

  Recombinant Proteins

• Source :

  E. coli

• Buffer :

  Lyophilized from a 0.2 um filtered solution of 20mM Tris,150mM NaCl, 4M Urea, pH 8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions :

  Room Temp

• Calculated Molecular Weight :

  29.3 kD

• Applications Notes :

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name :

  Erb-b2 receptor tyrosine kinase 2

• NCBI Organism :

  Rattus norvegicus

• Other Product Names :

  Receptor tyrosine-protein kinase erbB-2, Epidermal growth factor receptor-related protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, p185neu, CD340, ERBB2., Her2

• Species :

  Rat

• Physical Properties :

  Lyophilized

• CAS Number :

  9000-83-3