EpCAM Recombinant Protein

• Background:

  EpCAM is also known as CO171A, EGP, EGP40, GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A (mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

• NCBI Gene ID:

  17075

• Swiss Prot:

  Q99JW5

• Accession Number:

  AAH05618.1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Purity:

  >98% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  28.5 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Epithelial cell adhesion molecule

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Linnenbach, et al., 1993, Mol Cell Biol 13 (3) : 1507–15.

• Background Reference 02:

  Akita H, et al., 2011, Oncogene.

• Background Reference 03:

  Winter MJ, et al., 2007, Mol Cell Biochem. 302 (1-2) :19-26.

• Background Reference 04:

  Schmidt M, et al., 2011, Breast Cancer Res Treat. 125 (3) :637-46.

• Other Product Names:

  EPCAM, TACSTD1, TROP1, CD326, DIAR5, EGP2, EGP314, EGP40, ESA, GA733-2, HNPCC8, HNPCC-8, KS1/4, KSA, M4S1, MIC18, MK1

• Tested Applications:

  WB

• Species:

  Mouse

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3