EpCAM Antibody

• Background:

  This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

• NCBI Gene ID:

  4072

• Swiss Prot:

  P16422

• Accession Number:

  P16422

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This EpCAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-229 amino acids from the C-terminal region of human EpCAM.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  35 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  EPCAM

• NCBI Official Name:

  Epithelial cell adhesion molecule

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kimura, O., et al. Cancer Sci. 101 (10) :2145-2155 (2010)

• Background Reference 02:

  Jiang, L., et al. Breast Cancer Res. Treat. (2010) In press :

• Background Reference 03:

  Lugli, A., et al. Br. J. Cancer 103 (3) :382-390 (2010)

• Background Reference 04:

  Johnatty, S.E., et al. PLoS Genet. (7), E1001016 (2010) :

• Other Product Names:

  Epithelial cell adhesion molecule, Ep-CAM, Adenocarcinoma-associated antigen, Cell surface glycoprotein Trop-1, Epithelial cell surface antigen, Epithelial glycoprotein, EGP, Epithelial glycoprotein 314, EGP314, hEGP314, KS 1/4 antigen, KSA, Major gastrointestinal tumor-associated protein GA733-2, Tumor-associated calcium signal transducer 1, CD326, EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1

• Tested Applications:

  WB

• Protein ID:

  160266056

• Physical Properties:

  Liquid