DNAM-1 Recombinant Protein

• Background:

  DNAX accessory molecule 1 (DNAM-1), a single-pass type I membrane protein, is also known as CD226 antigen and platelet and T cell activation antigen 1 (PTA1), which contains 2 Ig-like C2-type (immunoglobulin-like) domains. DNAM-1 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.

• NCBI Gene ID:

  10666

• Swiss Prot:

  Q15762-1

• Accession Number:

  NP_006557

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology

• Buffer:

  Tris with Glycine, Arginine and NaCl, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  52.6 kDa

• Applications Notes:

  This recombinant protein can be used for E, WB. For research use only.

• NCBI Official Name:

  CD226 antigen isoform a precursor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Shibuya A., et al.,1995, Immunity 4:573-581.

• Background Reference 02:

  Tahara-Hanaoka S., et al .,2003, Int. Immunol. 16:533-538.

• Background Reference 03:

  Pende D., et al.,2004, Mol. Immunol. 42:463-469.

• Other Product Names:

  DNAM1, CD226, PTA1

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3