Dickkopf-related protein 1 Recombinant Protein

• Background:

  Dickkopf-related protein 1 (DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

• NCBI Gene ID:

  22943

• Swiss Prot:

  O94907

• Accession Number:

  O94907

• Tag:

  N-8 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Cell Cycle, Immunology, Signal Transduction

• Buffer:

  Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  27 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Dickkopf WNT signaling pathway inhibitor 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Dickkopf-related protein 1, Dickkopf-1, Dkk-1

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3