IL-6 Recombinant Protein

• Background:

  Cytokines of the IL6/GCSF/MGF family are glycoproteins of about 170 to 180 amino acid residues that contain four conserved cysteine residues involved in two disulfide bonds. They have a compact, globular fold (similar to other interleukins), stabilized by the 2 disulfide bonds. One half of the structure is dominated by a 4 alpha-helix bundle with a left-handed twist; the helices are anti-parallel, with 2 overhand connections, which fall into a 2-stranded anti-parallel beta-sheet. The fourth alpha helix is important to the biological activity of the molecule. Interleukin-6 (IL-6) is an important proinflammatory and immunoregulatory cytokine expressed by various cells. Interleukin-6 has been shown to inhibit the growth of early stage and to promote the proliferation of advanced stage melanoma cells in vitro.

• NCBI Gene ID:

  3569

• Swiss Prot:

  P05231

• Accession Number:

  P05231

• Tag:

  Tag Free

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Cancer, Chemokines & Cytokines, Immunology, Neuroscience, Obesity, Signal Transduction

• Buffer:

  Lyophilized from a 0.2 um filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 5.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  20.9 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Interleukin 6

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Interleukin-6, IL-6, B-Cell Stimulatory Factor 2, BSF-2, CTL Differentiation Factor, CDF, Hybridoma Growth Factor, Interferon Beta-2, IFN-Beta-2, IL6, IFNB2

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3